umr216.ird.fr

1 - Parasitology

Parasitology

Our work is dedicated to study patho-physiological mechanisms during infectious diseases, including pregnancy-associated malaria, as well as theirs consequences for the health of the mother, the offspring, and the infant. Programs include 4 mains domains:

  • Host factors involved in modulating humoral and cellular immune response: study of malaria-related immune response variations, and consequences for the newborn and the infant.
  • Parasite factors involved in clinical symptoms of malaria: the studied parasite factor is rbc adhesion to endothelial cells, with a cell and molecular approach.
  • Vaccine design in the context of pregnancy-associated malaria, involving the induction of immunity blocking the adhesion of infected rbc to the placenta.
  • Biochemical identification of therapeutic targets, privileging two metabolic pathways: transports to and outside the parasite digestive vacuole and the phosphorylation/déphosphorylation cycles via protein kinase A.

Team leader : Philippe Deloron

Staff presentation

Philippe DELORON

Unit Manager

Manager implementation France

Manager Hote Parasite Relations Team

Research Director HDR

Pilot process quality

Head of Unit, Host-parasite relationships team leader, MD, PhD, parasitologist, work on characterization of parasites involved in pregnancy-associated malaria

Phone : +33 1 53 73 96 22

Email : philippe.deloron@ird.fr

Sandrine HOUZE

Hospital Doctor (PH)

University professor HDR

Research on malaria: diagnosis, treatment, epidemiology.

Activities clinical biology of parasitic and fungal diseases supported the hospital (malaria, intestinal parasites, toxoplasmosis, leishmaniasis, fungal diseases)

http://www.cnrpalu-france.org/

Phone : +33 1 40 25 78 97

Email : sandrine.houze@bch.aphp.fr

Nicaise Tuikue NDAM

Researcher HDR

Phone : +229 96 20 28 36

Email : nicaise.ndam@ird.fr

Rachida TAHAR

Researcher HDR

The objective of our studies is to investigate the role of variant surface antigens in the cytoadhesion of infected erythrocytes to cellular receptors, including ICAM-1, PECAM-1, VCAM-1, CD36, CSA) as well as the ability of these genes to trig the immune system of the host and produce active antibodies efficient to inhibit the cytoadhesion process.

Phone : +33 1 70 64 94 34

Email : Rachida.Tahar@ird.fr

Anaïs MERCKX

Associate Professor (MCU)

Pilot process quality

I work on signal transduction pathways in Plasmodium falciparum infected red blood cell (kinase, cAMP, PKA, AKAP) in order to identify new therapeutic targets.

I am teaching in animal biology and parasitology (School of Pharmacy and scientific studies (licence and master)) Supervising : Technicians, two year technical degree, Master PhD

Phone : +33 1 70 64 94 33

Email : anais.merckx@parisdescartes.fr

Audrey SABBAGH

Associate Professor (MCU)

Chair Joint University Paris Descartes/IRD

Research interests :

-Contribution of population genetics to the identification of genetic factors involved in malaria susceptibility and in childhood development of immunity.

-Genetic diversity and evolution of var2csa gene involved in pregnancy-associated malaria.

-Genetic diversity and structure of populations from Benin: impact on public health and medicine.

-Genetic diversity and evolutionary history of HLA-G involved in immune tolerance.

Phone : +33 1 53 73 96 20

Email : audrey.sabbagh@ird.fr

Jérôme CLAIN

Associate Professor (MCU)

Pilot process quality

My work addresses the evolution and the mechanisms of antimalarial drug resistance.

Phone : +33 1 70 64 94 33

Email : jerome.clain@parisdescartes.fr

Rémy DURAND

Associate Professor (MCU)

Hospital Doctor (PH)

Phone :

Email : remy.durand@avc.ap-hop-paris.fr

Romain DUVAL

researcher CR1

Phone : +33 1 53 73 99 33

Email : romarinduval@hotmail.fr

Sayeh GUEMOURI

University professor HDR

study of the factors involved in parasite cytoadherence of erythrocytes infected with Plasmodium falciparum in the placenta and causing malaria in pregnancy in pregnant women.

Thorough knowledge of polymorphism and genetic diversity of Plasmodium falciparum isolates from malaria patients (development of techniques for detecting polymorphism).

Mastery of the culture of Plasmodium falciparum.

Phone : +33 1 53 73 99 33

Email : sayeh.guemouri@ird.fr

Lydia BARATA

Phone :

Email : liseb@mail.med.upenn.edu

Talleh ALMELLI

PhD student

University of attachment: Descartes Paris 5

Phone : +33 1 53 73 96 21

Email : almelli_talleh@yahoo.fr

Gwladys BERTIN

Assistant Engineer

Prevention assistant

Phone : +33 1 53 73 96 21

Email : gwladys.bertin@ird.fr

Kossiwa BANDJE

PhD student

University of attachment: Descartes Paris 5

M2 2010 -2011

These 2011 - 2014

Phone :

Email : lalabandje@yahoo.fr

Justin DORITCHAMOU

PhD student

Phone : +229 97 69 74 92

Email : jdorichamou@yahoo.fr

Nicolas ARGY

Phone :

Email : nicolas.argy@gmail.com

Murielle LOHEZIC

Technical Assistant

Pilot process quality

Phone : +33 1 53 73 96 18

Email : murielle.lohezic@parisdescartes.fr